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Effect of NaHS and capsazepine on liver dysfunction and lung edema in septic mice.

By Seah-Fang Ang (344469), Shabbir M. Moochhala (344471), Paul A. MacAry (175388) and Madhav Bhatia (330806)


<p>Mice were randomly given NaHS (10 mg/kg, i.p.) or vehicle (DMSO) at the same time of CLP; and capsazepine (<i>Capz</i>) (15 mg/kg, s.c.) or vehicle (DMSO) 30 minutes before CLP. Sham mice were used as controls. Eight hours after CLP or sham operation, plasma levels of (A) ALT and (B) AST, and (C) lung wet-to-dry weight ratio were measured. Results shown are the mean values ± SEM (n = 10–15 mice per group). *P<0.01 versus sham; **P<0.01 versus CLP+vehicle; ‡P<0.05 versus CLP+vehicle; †P<0.01 versus CLP+NaHS+vehicle.</p

Topics: Medicine, Microbiology, Cell Biology, Molecular Biology, Physiology, Immunology, nahs, capsazepine, dysfunction, edema, septic
Year: 2013
DOI identifier: 10.1371/journal.pone.0024535.g004
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Provided by: FigShare
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