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Effect of PAG and capsazepine on protein levels of cytokines and chemokines in the lungs and liver of septic mice.

By Seah-Fang Ang (344469), Shabbir M. Moochhala (344471), Paul A. MacAry (175388) and Madhav Bhatia (330806)


<p>Mice were randomly given PAG (50 mg/kg, i.p.) 1 hour before (“prophylactic”; PAG+CLP+Vehicle or PAG+CLP+Capz) or 1 hour after (“therapeutic”; CLP+PAG+Vehicle or CLP+PAG+Capz) CLP; and capsazepine (<i>Capz</i>) (15 mg/kg, s.c.) or vehicle (DMSO) 30 minutes before CLP. Sham mice were used as controls. Eight hours after CLP or sham operation, protein levels of (A) TNF-α, (B) IL-1β, (C) IL-6, (D) MIP-1α and (E) MIP-2 were measured. Results shown are the mean values ± SEM (n = 8–12 mice per group). *P<0.01 versus sham; **P<0.01 versus CLP+vehicle; †P<0.05 versus CLP+vehicle.</p

Topics: Medicine, Microbiology, Cell Biology, Molecular Biology, Physiology, Immunology, pag, capsazepine, levels, cytokines, chemokines, lungs, septic
Year: 2013
DOI identifier: 10.1371/journal.pone.0024535.g006
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Provided by: FigShare
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