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The effect of <i>AKAP12</i> on the growth of human primary xenografts.

By Weiwei Liu (341566), Ming Guan (126815), Tingting Hu (233489), Xiaoye Gu (345310) and Yuan Lu (249915)

Abstract

<p>(A) <i>AKAP12</i> suppresses the growth of LoVo cells implanted in BALB/c nude mice. Mice injected with LoVo-AKAP12 cells displayed significantly reduced tumor volume compared with the animals injected with LoVo-CON or LoVo-LIPO cells four weeks after injection. (B) Tumor size was measured every week. Each point represents the mean volume ± SD on the X-axis. *<i>p</i><0.01, LoVo-AKAP12 versus LoVo-CON versus LoVo-LIPO. <i>p</i><0.01, LoVo-AKAP12 versus LoVo-CON. (C) Effect of <i>AKAP12</i> expression on the spontaneous metastasis of LoVo cells in nude mice. The quantitative real-time PCR amplification of the human Alu sequence and mouse <i>GAPDH</i> was performed using DNA extracts from the lung. (D) Western blot analysis of AKAP12 and cleaved-caspase-3 level in Lovo-CON and Lovo-AKAP12 group. AKAP12 and cleaved-caspase-3 were found to increase in the Lovo-AKAP12 group.</p

Topics: Cell Biology, Cancer, cell biology, oncology
Year: 2013
DOI identifier: 10.1371/journal.pone.0024015.g003
OAI identifier: oai:figshare.com:article/411642
Provided by: FigShare
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