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Cocaine induced regionally specific increases in FosB- IR in the dorsal striatum of male and female rats.

By Satoru M. Sato (349079), Anne Marie Wissman (170971), Andrew F. McCollum (349080) and Catherine S. Woolley (349081)

Abstract

<p>A) Bar graphs showing the percentage of all neurons in saline- (Sal) and cocaine- (Coc) treated male (M) and female (F) rats that were FosB-IR at any intensity level (Total FosB), and broken down into medium or darkly stained cells. B) Bar graphs showing the proportion of FosB-IR cells in each anatomical zone of the dorsal striatum. Each bar shows the percentage of all neurons in each treatment group that were light, medium, or darkly stained. Overall FosB-IR was higher in the Medial and Ventral, relative to the Lateral, zone, while cocaine-induced increases were most prominent in the Lateral zone. Additionally, females exhibited slightly higher FosB-IR than males. C) The partitioning scheme used to define Medial (M), Intermediate (I), Lateral (L), and Ventral (V) zones. D) A table summarizing the statistically significant differences (p<0.05) for dorsal striatum as a whole (Overall) and each of the zones. “D” indicates a significant drug effect, and “S” indicates a significant sex difference (See text).</p

Topics: Neuroscience, Physiology, Chemistry, Mental Health, induced, regionally, increases, fosb-, ir, dorsal, striatum
Year: 2013
DOI identifier: 10.1371/journal.pone.0021783.g004
OAI identifier: oai:figshare.com:article/431898
Provided by: FigShare
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