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The distributions of the primary outcome measure and other characteristics of plasma cortisol and plasma ACTH in the combined DEX-CRH test in 73 healthy first-degree relatives of patients with a history of major depressive disorder, in the escitalopram 10 mg group (N = 38) and the placebo group (N = 35).

By Ulla Knorr (180383), Maj Vinberg (180388), Allan Hansen (349256), Marianne Klose (349257), Ulla Feldt-Rasmussen (317604), Linda Hilsted (349260), Jørgen Hasselstrøm (349261), Ulrik Gether (180401), Per Winkel (156704), Christian Gluud (51497), Jørn Wetterslev (149392) and Lars Vedel Kessing (176727)


<p>Δ was the difference between the measurement of plasma cortisol and ACTH after and before four weeks of intervention with escitalopram 10 mg or placebo for: AUC<sub>total</sub> = Area under the curve after administration of CRH corrected for baseline equivalent, BASAL = mean of five measurements at the baseline after pre-treatment with dexametasone 1.5 mg and before the administration of CRH, PEAK = the highest measurement following CRH administration,</p>a)<p>Δplasma cortisol AUC<sub>total</sub> was the primary outcome measure.</p>b)<p><i>p</i> of Mann-Whitney test comparing the two distributions which did not follow normal distributions (Shapiro Wilkes test).</p><p>*95% C.I. are reported since the distributions followed normal distributions.</p

Topics: Pharmacology, Chemistry, Mental Health, distributions, characteristics, plasma, cortisol, acth, dex-crh, 73, first-degree, relatives, patients, depressive, escitalopram, 10, mg, placebo
Year: 2013
DOI identifier: 10.1371/journal.pone.0021224.t004
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Provided by: FigShare
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