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FTY720 does not reduce infarct volume after cortical permanent ischemia.

By Arthur Liesz (349478), Li Sun (4624), Wei Zhou (24328), Sönke Schwarting (349480), Eva Mracsko (349482), Markus Zorn (349484), Henrike Bauer (349486), Clemens Sommer (305673) and Roland Veltkamp (349489)

Abstract

<p>Animals in the treatment groups (FTY720) received daily administrations of 1 mg/kg FTY720 by oral gavage starting at 48 h before infarct induction.I Infarct volumes were determined (<b>A</b>) at 3d (n = 8 per group, p = 0.73, 2 individual experiments) and (<b>B</b>) at 7d (n = 17, 0.54, 4 individual experiments) after infarct induction. Control animals received daily PBS injections. (<b>C</b>) Animals were treated daily with either FTY720 or PBS, starting from 3 h after MCAO and infarct volumes were determined at 7d after brain ischemia (n = 10, p = 0.43, 2 individual experiments). (<b>D</b>) Mice received a single dose of FTY720 or PBS at 48 h before brain ischemia and infarct volumetry was performed at day 7 (n = 10, p = 0.27). Behavioural dysfunction and recovery after experimental stroke was assessed in FTY720 pretreated animals (daily treatment starting 48 h before MCAO) or in control animals by the (<b>E</b>) “cylinder test” (n = 12, 3 individual experiments) and the (<b>F</b>) “corner test” (n = 12, 3 individual experiments).</p

Topics: Neuroscience, Pharmacology, Immunology, infarct, cortical
Year: 2013
DOI identifier: 10.1371/journal.pone.0021312.g002
OAI identifier: oai:figshare.com:article/434144
Provided by: FigShare
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