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Long-term Continuous CORT treatment decreases Flk1 protein levels <i>in vitro</i> and <i>in vivo</i>.

By Kristy R. Howell (350779), Ammar Kutiyanawalla (341557) and Anilkumar Pillai (317120)

Abstract

<p>(<i>A</i>) CORT (CORT; I µM) was applied to mouse primary cortical neurons at DIV 5. Flk1 protein levels were determined by western blotting analysis at 48 hand 72 h following CORT treatment. CON means DMSO treatment. Data represent mean±SE. (<i>n</i> = 6) expressed as fold change in Flk1 protein levels as compared to CON. β-actin is the loading control. *<i>P</i><0.05 (Bonferroni's test). (<i>B</i>) Flk1 protein levels in frontal cortex of mice treated with CORT or vehicle control (CON; 0.45% hydroxypropyl-β-cyclodextrin) for 7 weeks. Data represent mean±SE (<i>n</i> = 6–8) expressed as fold change in Flk1 protein levels as compared to CON. *<i>P</i><0.01 (t test).</p

Topics: Mental Health, cort, decreases, flk1, levels
Year: 2013
DOI identifier: 10.1371/journal.pone.0020198.g001
OAI identifier: oai:figshare.com:article/441041
Provided by: FigShare
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