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Sodium channel properties in wt and dystrophic neonatal cardiomyocytes.

By Xaver Koenig (152027), Sandra Dysek (224774), Stefanie Kimbacher (350997), Agnes K. Mike (350999), Rene Cervenka (351001), Peter Lukacs (234863), Katrin Nagl (351002), Xuan B. Dang (351003), Hannes Todt (351004), Reginald E. Bittner (224788) and Karlheinz Hilber (351005)

Abstract

<p><b>A.</b> Original current traces of a typical wt, mdx, and mdx-utr cardiomyocyte, elicited by depolarising voltage-steps. <b>B.</b> Current-voltage relationships derived from a series of experiments as shown in A. The Inset (bar graph) shows a comparison of the maximum current densities between wt and dystrophic cardiomyocytes. <b>C.</b> Comparison of the current decay kinetics between wt and dystrophic cardiomyocytes at different membrane voltages. Decay half-times represent the time periods between the current peak and the time point at which the current had decayed to 50%. * indicates that ANOVA revealed a significant difference (p<0.05) between the respective parameters of the three tested groups. Tukey's Post Hoc test for comparison between two groups revealed significant differences (p<0.05) between mdx-utr and wt, and between mdx-utr and mdx. <b>D.</b> Voltage-dependencies of activation and steady-state inactivation in wt and dystrophic cardiomyocytes. <b>E.</b> Recovery from inactivation in wt and dystrophic cardiomyocytes. Data were fit with a single exponential function. The pulse protocols are shown as insets in the respective graphs. Data points represent means ± SEM. Detailed statistics and n-values are given in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0020300#pone-0020300-t001" target="_blank">Table 1</a>.</p

Topics: Physiology, properties, wt, dystrophic, neonatal
Year: 2013
DOI identifier: 10.1371/journal.pone.0020300.g001
OAI identifier: oai:figshare.com:article/442554
Provided by: FigShare
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