Article thumbnail

5-HT<sub>3A</sub> CNiFER: Ondansetron antagonism.

By John G. Yamauchi (356829), Ákos Nemecz (356830), Quoc Thang Nguyen (356831), Arnaud Muller (19570), Lee F. Schroeder (356832), Todd T. Talley (356833), Jon Lindstrom (356834), David Kleinfeld (72230) and Palmer Taylor (40801)

Abstract

<p>A. Competitive blockade of 5-HT elicited responses on 5-HT<sub>3A</sub> CNiFERs by ondansetron. The steep Hill coefficient of 2.6 shows the more cooperative nature of the 5-HT<sub>3A</sub> receptor. The EC<sub>50</sub> values for each curve shifted from 220 nM to 1.6 µM, 2.6 µM, and 4.5 µM for 5 nM, 10 nM, 15 nM ondansetron respectively. B. Schild plot of concentration dependent shifts. A slope of -1.3±0.04 confirmed ondansetron to block competitively.</p

Topics: Biochemistry, Neuroscience, Pharmacology, ondansetron
Year: 2013
DOI identifier: 10.1371/journal.pone.0016519.g006
OAI identifier: oai:figshare.com:article/473213
Provided by: FigShare
Download PDF:
Sorry, we are unable to provide the full text but you may find it at the following location(s):
  • https://figshare.com/articles/... (external link)

    • Suggested articles


    To submit an update or takedown request for this paper, please submit an Update/Correction/Removal Request.