<p>A. Competitive blockade of 5-HT elicited responses on 5-HT<sub>3A</sub> CNiFERs by ondansetron. The steep Hill coefficient of 2.6 shows the more cooperative nature of the 5-HT<sub>3A</sub> receptor. The EC<sub>50</sub> values for each curve shifted from 220 nM to 1.6 µM, 2.6 µM, and 4.5 µM for 5 nM, 10 nM, 15 nM ondansetron respectively. B. Schild plot of concentration dependent shifts. A slope of -1.3±0.04 confirmed ondansetron to block competitively.</p
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