5-HT_3A CNiFER: Ondansetron antagonism.

Abstract

<p>A. Competitive blockade of 5-HT elicited responses on 5-HT_3A CNiFERs by ondansetron. The steep Hill coefficient of 2.6 shows the more cooperative nature of the 5-HT_3A receptor. The EC₅₀ values for each curve shifted from 220 nM to 1.6 µM, 2.6 µM, and 4.5 µM for 5 nM, 10 nM, 15 nM ondansetron respectively. B. Schild plot of concentration dependent shifts. A slope of -1.3±0.04 confirmed ondansetron to block competitively.</p