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5-HT<sub>3A</sub> CNiFER: Ondansetron antagonism.

By John G. Yamauchi (356829), Ákos Nemecz (356830), Quoc Thang Nguyen (356831), Arnaud Muller (19570), Lee F. Schroeder (356832), Todd T. Talley (356833), Jon Lindstrom (356834), David Kleinfeld (72230) and Palmer Taylor (40801)


<p>A. Competitive blockade of 5-HT elicited responses on 5-HT<sub>3A</sub> CNiFERs by ondansetron. The steep Hill coefficient of 2.6 shows the more cooperative nature of the 5-HT<sub>3A</sub> receptor. The EC<sub>50</sub> values for each curve shifted from 220 nM to 1.6 µM, 2.6 µM, and 4.5 µM for 5 nM, 10 nM, 15 nM ondansetron respectively. B. Schild plot of concentration dependent shifts. A slope of -1.3±0.04 confirmed ondansetron to block competitively.</p

Topics: Biochemistry, Neuroscience, Pharmacology, ondansetron
Year: 2013
DOI identifier: 10.1371/journal.pone.0016519.g006
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Provided by: FigShare
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