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Tau phosphorylation in mouse cortical tissue 30 min and 2 h following the administration of propofol under normothermic conditions.

By Robert A. Whittington (356824), László Virág (219742), François Marcouiller (317637), Marie-Amélie Papon (356825), Noura B. El. Khoury (356826), Carl Julien (132802), Françoise Morin (356827), Charles W. Emala (356828) and Emmanuel Planel (142072)

Abstract

<p>Cortical protein extracts were separated by SDS-PAGE and levels of tau phosphorylation were determined using antibodies directed at the AT8 (<i>1</i>), PHF-1 (<i>2</i>), pS262 (<i>3</i>), MC6 (<i>4</i>), and pS422 (<i>5</i>) phophoepitopes, or Total Tau (<i>6</i>). Relative immunoreactive band intensities are expressed as a percent of control (Ctl; intralipid) and are displayed for each phosphoepitope and total tau. For each condition, 1 representative datum is displayed with Ctl (n = 6), 0.5 h (n = 6), and 2 h (n = 7). Data are expressed as mean ± SD. *, and ** and denote <i>P</i><0.05, and <i>P</i><0.01 vs. Ctl, respectively; ANOVA with Newman-Keuls <i>post hoc</i> test.</p

Topics: Medicine, Neuroscience, phosphorylation, cortical, 30, min, propofol, normothermic
Year: 2013
DOI identifier: 10.1371/journal.pone.0016648.g004
OAI identifier: oai:figshare.com:article/473333
Provided by: FigShare
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