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GFAP and CS-56 expression at the lesion site.

By Anjana Jain (357160), Robert J. McKeon (357161), Susann M. Brady-Kalnay (137049) and Ravi V. Bellamkonda (357163)

Abstract

<p><b>A</b>. Images of the lesion site for the controls and treated conditions that show the GFAP stain for reactive astrocytes at 10×. The white box represents the focused image (20×) to the right of CS-56 (red) and GFAP (blue), respectively. The rows of images are untreated spinal cord, Agarose, BDNF, CA-Cdc42, and CA-Rac1. <b>B</b>. The GFAP intensity for BDNF, CA-Cdc42, and CA-Rac1 compared to the untreated control is significantly less. CA-Cdc42 was significantly less intense compared to the agarose control. The data represent the mean. One way ANOVA and Tukey's test were used to statistically analyze the data. The gray lines represent the ± SEM. (p<0.05 BDNF, CA-Cdc42, and CA-Rac1 compared to untreated control, p<0.05 CA-Cdc42 compared to agarose control). <b>C</b>. The CS-56 intensity was significantly lower in spinal cords treated with CA-Cdc42 and BDNF compared to the untreated and agarose controls. The data represent the mean. The gray lines represent ± SEM. (p<0.05 CA-Cdc42 and BDNF compared to untreated and agarose controls).</p

Topics: Neuroscience, Physiology, Pharmacology, Biotechnology, cs-56, lesion
Year: 2013
DOI identifier: 10.1371/journal.pone.0016135.g002
OAI identifier: oai:figshare.com:article/474550
Provided by: FigShare
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