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Percentage of the total administered dose of hASM detected in the (A) brain, (B) spinal cord and (C) serum of rats following 6 h ICV infusion.

By Christopher M. Treleaven (357225), Thomas Tamsett (357226), Jonathan A. Fidler (357227), Tatyana V. Taksir (357229), Seng H. Cheng (142952), Lamya S. Shihabuddin (357231) and James C. Dodge (357233)


<p>Animals were infused with 0.1, 1.0 or 10 mg/kg of hASM or aCSF. For both the brain and spinal cord, less than 0.2% of the total dose could be detected in each region. Cumulatively, the level of hASM detected in the brain and spinal cord was less than 1% of the total dose administered. No significant differences were observed between regions or different dose groups. Significant (p<.01) levels of hASM were detected in serum for each dose.</p

Topics: Biochemistry, Genetics, Neuroscience, Physiology, Pharmacology, Biotechnology, administered, hasm, spinal, serum, rats, icv
Year: 2013
DOI identifier: 10.1371/journal.pone.0016313.g003
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Provided by: FigShare
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