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Morbid obesity in <i>Leptin<sup>145E/145E</sup></i> mice.

By Chen-Jee Hong (160996), Pei-Jane Tsai (300286), Chih-Ya Cheng (160978), Chuan-Kai Chou (358945), Huei-Fen Jheng (358946), You-Chung Chuang (358947), Chia-Ning Yang (358948), Ya-Tzu Lin (167674), Chih-Wei Hsu (358950), Irene H. Cheng (167685), Shiow-Yi Chen (160980), Shih-Jen Tsai (160992), Ying-Jay Liou (160977) and Yau-Sheng Tsai (300287)


<p>(<b>A</b>) Increased body weight in <i>Leptin<sup>145E/145E</sup></i> mice compared with their <i>Leptin<sup>145E/+</sup></i> and <i>Leptin<sup>+/+</sup></i> littermates. (<b>B</b>) Growth curves and photograph of male <i>Leptin<sup>145E/145E</sup></i> mice (n = 5) and their <i>Leptin<sup>+/+</sup></i> littermates (n = 9). (<b>C</b>) Body lengths of 4-month-old male <i>Leptin<sup>145E/145E</sup></i> and <i>Leptin<sup>+/+</sup></i> mice. (<b>D</b>) Organ weights from <i>Leptin<sup>145E/145E</sup></i> (n = 11) and <i>Leptin<sup>+/+</sup></i> mice (n = 19). (<b>E</b>) Liver histology of <i>Leptin<sup>145E/145E</sup></i>and <i>Leptin<sup>+/+</sup></i> mice. Numbers of mice are inside bars. **<i>P</i><0.01 and ***<i>P</i><0.001 between two genotypes.</p

Topics: Genetics, Physiology, Chemistry, obesity
Year: 2013
DOI identifier: 10.1371/journal.pone.0015333.g002
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Provided by: FigShare
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