Discordance Associated Mutations (DAMs) within HIV-1PR alters the loss of mitochondrial transmembrane potential.

Abstract

<p>YFP HIV protease or the indicated protease point mutants were expressed in HeLa cells, and the YFP positive cells were analyzed for loss of mitochondrial transmembrane potential (A, B). *Indicates p value ≤0.05. Data reflective of at least three independent replicates. Bars with solid color represent controls, bars with angled hatching represent DAMs, and bars with horizontal hatching represent non-DAMs.</p