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Relationships between the most significant genetic covariates and estimates for each of the 4 PK parameters from univariate analysis in the phase I dataset.

By Wenjun Ni (117934), Jia Ji (6513), Zunyan Dai (86226), Audrey Papp (252886), Amy J. Johnson (360182), Sunjoo Ahn (360184), Katherine L. Farley (360186), Thomas S. Lin (360188), James T. Dalton (238784), Xiaobai Li (152726), David Jarjoura (269395), John C. Byrd (14625), Wolfgang Sadee (179657), Michael R. Grever (283609) and Mitch A. Phelps (360193)

Abstract

<p>Box plots represent the scatter of individual V1 estimates vs. SLCO1B1 rs11045819 (Panel A), CL estimates vs. SLCO1B1 rs4149056 (Panel B), and V2 estimates vs. ABCC2 rs8187710 (Panel C). For rs11045819, data is displayed with V1 estimates using BSV on V1.</p

Topics: Genetics, Pharmacology, covariates, estimates, pk, parameters, univariate
Year: 2013
DOI identifier: 10.1371/journal.pone.0013792.g002
OAI identifier: oai:figshare.com:article/491218
Provided by: FigShare
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