Relationships between the most significant genetic covariates and estimates for each of the 4 PK parameters from univariate analysis in the phase I dataset.
<p>Box plots represent the scatter of individual V1 estimates vs. SLCO1B1 rs11045819 (Panel A), CL estimates vs. SLCO1B1 rs4149056 (Panel B), and V2 estimates vs. ABCC2 rs8187710 (Panel C). For rs11045819, data is displayed with V1 estimates using BSV on V1.</p
Genetics, Pharmacology, covariates, estimates, pk, parameters, univariate
DOI identifier: 10.1371/journal.pone.0013792.g002
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