Contribution of S100A8/A9 to cytokine and chemokine production during UTI.

Abstract

<p>Chemokine and cytokine levels (KC, MIP-2 and TNF-α) in bladder (<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0013394#pone-0013394-g004" target="_blank">figure 4A–C</a>) and kidney (<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0013394#pone-0013394-g004" target="_blank">figure 4D–F</a>) homogenates from WT mice (black squares) and S100A9 KO mice (white squares), 24 and 48 hours after inoculation with 4.5×10⁸ or 9.0×10⁸ CFU <i>E. coli</i>/mouse. Sham mice were sacrificed 24 hours after inoculation with sterile PBS. Single experimental data are mean ± SEM. N = 6–9 mice per group, *P<0.05 vs. WT mice.</p

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