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EGR-2 deficient mice mount a normal T cell response against LCMV.

By Hilda E. Ramón (361383), Pedro J. Cejas (361384), David LaRosa (361386), Adeeb Rahman (361388), John E. Harris (361390), Jidong Zhang (361392), Christopher Hunter (361394), Yongwon Choi (268213) and Laurence A. Turka (361396)

Abstract

<p>WT or EGR-2 CKO mice were infected with 2×10<sup>5</sup> PFU of LCMV Armstrong. (A) The number of CD8 T cells specific for gp33 or np396 was measured by staining with MHC-class I tetramers, on days 5, 8, and 15. (B) The percentage of CD8 cells that were IFN-γ producers was analyzed by intracellular cytokine staining after restimulation with LCMV pooled peptide. For all graphs, three mice were analyzed for each genotype on each time point.</p

Topics: Immunology, deficient, mice
Year: 2013
DOI identifier: 10.1371/journal.pone.0012904.g005
OAI identifier: oai:figshare.com:article/498199
Provided by: FigShare
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