Synthesis of WRR-483 (2):

Yen Ting Chen (361838); Linda S. Brinen (247688); Iain D. Kerr (247678); Elizabeth Hansell (203763); Patricia S. Doyle (345076); James H. McKerrow (113918); William R. Roush (361839)

doi:10.1371/journal.pntd.0000825.g002

Synthesis of WRR-483 (2):

By Yen Ting Chen (361838), Linda S. Brinen (247688), Iain D. Kerr (247678), Elizabeth Hansell (203763), Patricia S. Doyle (345076), James H. McKerrow (113918) and William R. Roush (361839)

Abstract

(a) (i) benzyl alcohol (BnOH), 4-dimethylaminopyridine, 1-ethyl-3-(3′-dimethylaminopropyl)carbodiimide hydrochloride (EDC), N-methylmorpholine, CH2Cl2; (ii) piperidine, CH2Cl2, 90% (two steps); (b) (i) triphosgene, sodium bicarbonate (NaHCO3), CH2Cl2; (ii) N-methylpiperazine, CH2Cl2, 93% (two steps); (c) H2, 5% palladium on carbon (Pd/C), MeOH, 92% (d) (i) trifluoroacetic acid (TFA), CH2Cl2; (ii) 6, N-hydroxybenzotriazole (HOBT), 1-ethyl-3-(3′-dimethylaminopropyl)carbodiimide hydrochloride (EDC), N-methylmorpholine, dimethyl formamide (DMF), CH2Cl2, 84%; (g) 3:1 TFA:CH2Cl2, 86%.</p

Topics: Biochemistry, Physics, Medicine, Pharmacology, Chemistry, wrr-483

Year: 2013

DOI identifier: 10.1371/journal.pntd.0000825.g002

OAI identifier: oai:figshare.com:article/501188

Provided by: FigShare

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Synthesis of WRR-483 (2):

Abstract

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