<p>Microcolonies of RIF susceptible strain H37Ra and resistant strain HR1 were grown without RIF for 7 days, then moved to fresh agar with or without RIF from day 7 onwards. A, C: Averaged sizes of H37Ra (A) and HR1 (C) colonies incubated with (open symbols) and without RIF (closed symbols). Average colony size is plotted; bars indicate ±1 standard deviation of measured colony sizes. A statistically significant difference (indicated by an asterisk (*), p<0.001) between the groups at day 7 and 8 (unpaired T-test) was found between H37Ra with and without RIF at day 8. B: Growth rate of individual H37Ra (B) and HR1 (D) colonies incubated with (white bars) and without (black bars) RIF. Statistical analysis was performed using a paired T-test on colony growth between day 6 and day 7, and day 6 and day 8. Statistical significance is indicated by an asterisk (*; p<0.001). Although there is a statistically significant difference between the growth rate of HR1 at day 6 and 7 in the presence of RIF, the change in growth rate is so small compared to the sensitive strain that we consider this effect irrelevant.</p
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