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PGN-SA stimulation induced STAT3 and Smad3 activation via TLR2.

By Wenjie Xie (364477), Yafang Huang (166269), Wenling Xie (364479), Aimin Guo (364481) and Wei Wu (27708)


<p>(A, B, C and D) Phospho-STAT3 and Phospho-Smad3 were detected in cancer cells using flow cytometry assay and equal volume of PBS treatment served as a control. STAT3 and Smad3 activation were all enhanced by PGN-SA stimulation whereas TLR2 blockade hampered STAT3 and Smad3 activation. (C and D) On contrast to TLR2-low cell line MCF-7, MDA-MB-231 cells showed more sensitive to PGN-SA stimulation. Values were expressed as mean ± SD (n = 6 <i>*P</i><0.05; <i>**P</i><0.01).</p

Topics: Medicine, Cell Biology, Cancer, Plant Biology, stimulation, induced, stat3, smad3, activation
Year: 2013
DOI identifier: 10.1371/journal.pone.0010850.g005
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Provided by: FigShare
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