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Knockout effects of genes containing SNPs found in GWA.

By Maria Sardi (3221436), Vaishnavi Paithane (4884367), Michael Place (36014), De Elegant Robinson (4884373), James Hose (197698), Dana J. Wohlbach (4884370) and Audrey P. Gasch (197708)

Abstract

<p>Genes linked to SNPs implicated by GWA were deleted in one or two genetic backgrounds, tolerant strain YPS128 (A) and sensitive strain YJM1444 (B). Significance was determined by paired T-test (where experiments were paired by replicate date, see <a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1007217#sec010" target="_blank">Methods</a>) with FDR correction compared to respective wild type strain. Asterisks indicate FDR < 0.05 or p< 0.05 (which corresponds to FDR of ~13%), according to the key. Deletion strains in (B) are ordered as in (A); NA indicates missing data due our inability to make the gene deletion in that background. <i>zrt1-adh4Δ</i> indicates the deletion of an intergenic sequence between these genes.</p

Topics: Microbiology, Genetics, Ecology, Infectious Diseases, Space Science, Environmental Sciences not elsewhere classified, Biological Sciences not elsewhere classified, GWA, strain background, mechanism, toxin tolerance, Saccharomyces cerevisiae strains, 165 Saccharomyces cerevisiae strains, toxin tolerance Cellulosic plant biomass, gene
Year: 2018
DOI identifier: 10.1371/journal.pgen.1007217.g004
OAI identifier: oai:figshare.com:article/5919763
Provided by: FigShare
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