Hydrolysis and transglycosylation reactions using SG-oxazoline as donor substrates by Endo-S mutants.
<p>(A) Hydrolysis reactions were performed using trastuzumab and Endo-S mutants at a 50:1 weight ratio. (B) Transglycosylation reactions were carried out using deglycosylated trastuzumab as the acceptor and 5 molar eq of donor oxazoline.</p
Biophysics, Biochemistry, Medicine, Microbiology, Genetics, Biotechnology, Infectious Diseases, Space Science, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, mutant, Endo-S D 233Q D 233Q, endoglycosidase, mutation, oxazoline, efficiency, glycan, D 233Q, Streptococcus pyogenes, novel one-pot transglycosylation reaction, transglycosylation efficiencies, antibody
DOI identifier: 10.1371/journal.pone.0193534.g001
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