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Characterization of the rhesus macaque (<i>Macaca mulatta</i>) scrub typhus model: Susceptibility to intradermal challenge with the human pathogen <i>Orientia tsutsugamushi</i> Karp - Fig 7

By Piyanate Sunyakumthorn (288420), Suwit J. Somponpun (4925812), Rawiwan Im-erbsin (4427122), Tippawan Anantatat (288425), Kemajittra Jenjaroen (188764), Susanna J. Dunachie (362047), Eric D. Lombardini (387231), Robin L. Burke (4427128), Stuart D. Blacksell (101742), James W. Jones (150954), Carl J. Mason (2901956), Allen L. Richards (47617), Nicholas P. J. Day (35781) and Daniel H. Paris (188754)

Abstract

<p><b>Localization of intracellular <i>O</i>. <i>tsutsugamushi</i> in antigen presenting cells (APCs) in macaque tissues, (A and E) Eschar: BR1-02, (B) Spleen: BR1-02, (C) Draining lymph node (D-LN): BR1-03, (D) Non-draining lymph node (ND-LN): BR1-05 after 28 day pi.</b><i>O</i>. <i>tsutsugamushi</i> is labeled in green, APCs are characterized by MHC class II receptor (HLADR) and shown in red. Panels A-D show <i>O</i>. <i>tsutsugamushi</i> organisms associated with APCs in eschar, spleen, draining and non-draining lymph nodes. Panel E shows orthogonal views of confocal Z-stack images. DAPI nuclear counterstain in blue. Scale bars: 10 μm.</p

Topics: Medicine, Biotechnology, Ecology, Immunology, Cancer, Infectious Diseases, Virology, intradermal inoculation, future vaccine candidates, typhus disease model, well-characterized animal models, non-draining lymph nodes, tsutsugamushi Karp strain, day 14 pi, cell adhesion molecules, time course investigations, liver enzyme function, 10 6 murine LD 50, pathogen Orientia tsutsugamushi Karp Background, NHP, typhus model, response, study host immunity, rhesus macaques
Year: 2018
DOI identifier: 10.1371/journal.pntd.0006305.g007
OAI identifier: oai:figshare.com:article/5967667
Provided by: FigShare
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