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Photodynamic Therapy of Cancer Cells with Methanesulfonate Salts of 5-Aminolevulinic Acid and Its Derivatives

By Qiu XP, Kosobe T and Kawashima N

Abstract

A series of 5-aminolevulinic acid and its alkylester methanesulfonates was exploited to photodynamic therapy(PDT) of human lymphocytic cells, U-937 in vitro. The PDT efficiency is influenced by the concentration and incubation time. Generally, for ALA and its alkylester methanesulfonates, the cell survival rate decreases and the accumulation ability of PpIX increases with the concentration and incubation time. We found that the longer carbon chain methanesulfonates(C5-S, C6-S, C8-S) exhibit better PDT effect than ALA methanesulfonate. This possibly provides a promising route to the clinical application of PpIX-mediated PDT to cancer cell

Topics: IN-VITRO, AMINOLEVULINIC-ACID, SKIN, HEXYLESTER, VIVO, BIODISTRIBUTION, METHYLESTER, PENETRATION, CARCINOMA, KINETICS, In vitro, aminolevulinic acid, Skin, penetration, Tumors, Cancer, Dynamics, Cutis, Integument (Skin), dermatology, Ectoderm, Epidermis, 侵彻, EINDRINGUNG, PENETRATION (FRANCAIS), Permeation, Neoplasms, Tumours, oncology, Cancers, Carcinomas, Malignant Neoplasms, Sarcomas, cancer (disease), Carcinoma, Hepatoma, Sarcoma, Malignancy (Cancer), Malignant tumors, Neoplasia, Cancri, Cnc, Carcinogens, 动力学, Dynamical systems, Kinetics, Motion, Mechanics, Analytic, Analytical mechanics, robot dynamics, 动理学, 机器人动力学, CINETIQUES, KINETIK, REACTION RATES, robot motion
Year: 2010
OAI identifier: oai:ir.ciac.jl.cn:322003/43893
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