Objective: To investigate the levels of lipoprotein-associated phospholipase A2 (Lp-PLA2) and the polymorphisms of I198T and its relationship with coronary heart disease. Methods: In this study, 220 cases of coronary heart disease (CAD group) were selected as objective and 220 healthy people were collected as control group from January 2014 to December 2015. The gene polymorphism of I198T was detected by polymerase chain reaction (PCR). The levels of Lp-PLA2 were measured with immunoturbidimetry. The levels of high-sensitivity C -reactive protein (hs-CRP) were measured by radioimmunoassay. The levels of automatic biochemical analyzer glucose (GLU), cholesterol (TC), triglyceride (TG), low density lipoprotein (LDL-C), high density lipoprotein (HDL-C), lipoprotein a (LPa) of two groups were analyzed with automatic biochemical analyzer. Results: The levels of Lp-PLA2, TC, TG, HDL-C, LDL-C, hs-CRP, LPa of patients in CAD group were significantly higher than the control group (P<0.05). Pearson correlation analysis showed that Lp-PLA2 activity was positively correlated with HDL-C (r=0.421, P=0.000), LDL-C (r=0.396, P=0.000) and LPa (r=0.372, P=0.000). Logistic multivariate analysis showed the levels of Lp-PLA2, HDL-C, LDL-C were independent risk factor of CAD. The levels of Lp-PLA2 of Genotype II were higher than the genotype TT and IT, the difference was statistically significant (P<0.05). I198T point mutation on Lp-PLA2 was not correlated with CAD (P>0.05). Conclusions: Lp-PLA2 activity level is significantly higher in CAD, it can be considered as an independent risk factor for CAD. I198T point mutations on Lp-PLA2 has no correlation with CAD
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