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A novel synthetic adjuvant enhances dendritic cell function

By Karen S. M. Phillipps, Michelle N. Wykes, Xue Q. Liu, Melissa Brown, Joanne T. Blanchfield and Istvan Toth

Abstract

The lipid core peptide (LCP) is a novel, synthetic, self-adjuvanted vaccine delivery system that neatly incorporates the adjuvant, carrier and antigenic peptides of a vaccine into a single molecular entity. This system has been previously shown to efficiently deliver vaccines and induce immunity. Because adjuvants target sentinels of the immune response, such as dendritic cells (DCs), that are widely distributed throughout the body to initiate specific immune responses, we investigated the effects of the adjuvant on DCs. Here we show that LCP targets vaccines to DCs and induces their activation

Topics: Adjuvant, Dendritic cells, LCP system, Toll-like receptor 2, 2403 Immunology, 2723 Immunology and Allergy
Publisher: Wiley-Blackwell Publishing Ltd.
Year: 2009
DOI identifier: 10.1111/j.1365-2567.2008.03038.x
OAI identifier: oai:espace.library.uq.edu.au:UQ:197772
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