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Elucidating structure-function relationships from molecule-to-cell-to-tissue: from research modalities to clinical realities

By L. W. Dobrucki, B. J. Marsh and L. Kalinowski


The National Academy of Engineering selected ‘Imaging’ as one of the greatest engineering achievements of the 20th century (Greatest Engineering Achievements of the 20th Century. 2009 (cited 2008, November 10); available from: The combination of different imaging modalities and technologies for mapping bimolecular and/or biological processes within single cells or even whole organs has extraordinary potential for revolutionizing the diagnosis and treatment of pathophysiological disorders, and thus for mitigating the significant social and economic costs associated with the clinical management of disease. Such integrated imaging approaches will eventually lead to individualized programs for disease prevention through advanced diagnosis, risk stratification and targeted cell therapies resulting in more successful and efficient health care. The goal of this article is to provide readers with a current update of selected of state-of-the-art imaging modalities which would likely to lead to improved clinical outcomes if employed in an integrated approach, including use of ultramicrosensors to detect reactive oxygen/nitrogen species in a single cell, use of electron tomography to visualize and characterize cellular organization in three dimensions (3D), and molecular imaging strategies to assess naturally occurring and therapeutic peripheral and myocardial angiogenesis using targeted radiolabeled tracers

Topics: Biosensors, Nitric oxide, Superoxide, Peroxynitrite, Endotherlium, Endothelial nitric aoxide synthase, Cellular tomography, 970106 Expanding Knowledge in the Biological Sciences, 0601 Biochemistry and Cell Biology, 060108 Protein Trafficking
Publisher: Polish Physiological Society
Year: 2009
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