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Post-exposure treatment of DOG4 RV-infected mice with metyrapone blocks the rise in corticosterone associated with pathogenic RABV.

By Keith Schutsky (555469), Carla Portocarrero (555470), D. Craig Hooper (135220), Bernhard Dietzschold (369503) and Milosz Faber (555471)


<p>Mice were infected with 10<sup>4</sup> FFU of DOG4 RABV i.n. and either mock treated with PBS or treated with metyrapone (100 mg/kg) i.p. each day for 21 days. Ten mice per group were bled 1 hr after injection for each time point. The results represent comparative levels of corticosterone (+/− SE). *p<.05, **p<.01, and ***p<.001, respectively.</p

Topics: Biological Sciences, Biochemistry, metabolism, immunology, Clinical immunology, immunomodulation, immunotherapy, Immune suppression, immunity, Immunity to infections, microbiology, Virology, Viral transmission and infection, neurovirulence, Emerging viral diseases, Viral immune evasion, Viral replication, Viral vaccines, neuroscience, Neural homeostasis, systems biology, Veterinary science, Veterinary diseases, Zoonoses, rabies, Infectious diseases, Viral diseases, Pathology and laboratory medicine, pathogens, Virulence factors, dog4, rv-infected, mice, metyrapone, blocks, corticosterone, pathogenic
Year: 2014
DOI identifier: 10.1371/journal.pone.0087180.g006
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Provided by: FigShare
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