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ABR thresholds of mice with <i>Spns2</i> conditionally inactivated in different tissues.

By Jing Chen (4762), Neil Ingham (333137), John Kelly (582353), Shalini Jadeja (561467), David Goulding (125280), Johanna Pass (651903), Vinit B. Mahajan (119189), Stephen H. Tsang (119188), Anastasia Nijnik (651904), Ian J. Jackson (215017), Jacqueline K. White (119191), Andrew Forge (4688), Daniel Jagger (651905) and Karen P. Steel (114945)

Abstract

<p>ABR thresholds of individual mice are shown. All Cre driver lines showed normal thresholds (left column, in black. n = number of wildtype; number of mice carrying Cre). Most control littermates had normal responses (middle column: heterozygotes in blue; wildtypes in green). Homozygous <i>Spns2<sup>tm1d</sup></i> mutants (red) carrying the relevant Cre alleles are shown in the right column. <i>Spns2<sup>tm1d</sup></i> homozygotes carrying the Sox10-Cre allele had raised thresholds (top right), but the other four Cre lines had normal thresholds. The bottom row shows equivalent threshold data for the <i>Spns2<sup>tm1c</sup></i> allele and the Flp recombinase line used to generate this allele, again showing normal thresholds. There were three exceptions of individuals with raised thresholds (one heterozygote each in Pf4-Cre cross and Tie1-Cre cross, one homozygote in Tie1-Cre cross), which we believe probably carry an independent mutation causing the impairment (subject to ongoing positional cloning study).</p

Topics: Uncategorised, Onset Progressive Hearing Loss Spinster homolog 2, Spns 2, S 1P transporter, ep, Spinster Homolog 2, Spns 2 expression, strial capillaries, S 1P
Year: 2014
DOI identifier: 10.1371/journal.pgen.1004688.g010
OAI identifier: oai:figshare.com:article/1224262
Provided by: FigShare
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