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PI3K inhibition with LY294002 attenuated cystitis-induced bladder wall thickening and restored bladder capacity.

By Zhongwei Qiao (671515), Chunmei Xia (295039), Shanwei Shen (671516), Frank D. Corwin (671517), Miao Liu (148274), Ruijuan Guan (671518), John R. Grider (306218) and Li-Ya Qiao (490064)

Abstract

<p>The urinary bladders from cystitis animals (8 h, A) and cystitis animals treated with PI3K inhibitor LY294002 (CYP 8 h + LY, B) were visualized by MRI. Green circle indicated the outer edge of the urinary bladder (A, B); the pink circle indicated the inner edge of the urinary bladder (A, B). Treatment with LY294002 prevented bladder wall thickening caused by cystitis (C), and also increased the intravesical volume during cystitis (D). nā€Š=ā€Š4. *, p<0.05.</p

Topics: Biological Sciences, PI 3K inhibitor LY 294002, pcr, bladder hypertrophy, PI 3K pathway, Restores Bladder Capacity Examined, Magnetic resonance imaging, tumor necrosis factor, 48 h post CYP injection, MRI results, tnf, il
Year: 2014
DOI identifier: 10.1371/journal.pone.0114536.g002
OAI identifier: oai:figshare.com:article/1264460
Provided by: FigShare
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