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miR26b* and miR562 overexpression in MCF7 cells enhances endothelial cell angiogenesis while silencing miR26b* and miR562 inhibits angiogenesis.

By Durkeshwari Anbalagan (678647), Gracemary Yap (678648), Yi Yuan (180239), Vijay K. Pandey (678649), Wai Hoe Lau (678650), Suruchi Arora (678651), Pradeep Bist (528101), Justin S. B. Wong (102340), Gautam Sethi (109732), Peter M. Nissom (15810), Peter E. Lobie (118649) and Lina H. K. Lim (582763)

Abstract

<p>MCF7 cells were transfected with empty vector (EV), miR26b* or miR562 and a co-culture using transwells was performed with HUVEC in matrigel. (A,C) Average number of tubes formed per field of view and (B,D) average tube length was analyzed. Similar co-culture experiments were performed with MCF7 cells silenced with control, anti-miR26b* and anti-miR562. (D,G) Average number of tubes formed per field of view and (F,H) average tube length was analyzed. * p<0.05 ** p<0.01 vs control cells.</p

Topics: Biological Sciences, miR 26b, 2 novel miRNAs, MCF 7 breast cancer cells, ANXA 1, cell tube formation, miR 562, MCF 7 cells, tube formation, nf, Breast Cancer Cells Annexin 1, breast cancer metastasis, utr, wound healing, tnf
Year: 2014
DOI identifier: 10.1371/journal.pone.0114507.g006
OAI identifier: oai:figshare.com:article/1278347
Provided by: FigShare
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