Interleukin-1 receptor signaling controls MyD88-dependent chemokine induction and neutrophil recruitment.

Abstract

<p>Mean (+SEM) of (A, C) BALF, (B, D) lung neutrophil recruitment and (E, G, I) BALF and (F, H, J) lung, (E, F) CXCL1, (G, H) CXCL2 and (I, J) CXCL5 levels in WT (black bars), IL-1R^(−/−) (bars with diagonal stripes), IL-18R^(−/−) (bars with crosshatch), TLR2^(−/−) (dark grey bars), and TLR4^(−/−) (light grey bars) mice 10 h p.i. with 3 × 10⁷ conidia. Data are from 2 (A-D) or 1 (E-J) experiment(s) with 5–7 mice per genotype in each experiment. Graphs from a single experiment (out of three independent experiments) are shown for E, G and I.</p