Effects of <i>INMAP</i> overexpression on the expression of genes related to proliferation and apoptosis.
<p>(A). Western blot analysis of the three groups of cells (HeLa, Flag-HeLa, and Flag-INMAP) with anti-Bcl-2, anti-p53, anti-p21 and anti-PCNA antibodies. Data shown are representative of three independent experiments. (B). Band quantification was analysed with Image J software. (C). A schematic model illustrating the proposed mechanisms of <i>INMAP</i>-overexpression-induced DNA damage and apoptosis through p53-dependent pathways in transformed cells.</p
Biological Sciences, chromosome distortion, genomic stability, Induces Genomic Instability, p 53, xenograft growth, centromere integrality, pcna, INMAP Overexpression Inhibits Cell Proliferation, 2AX, monolayer cell cultures, p 21., lactate dehydrogenase, HeLa cells, growth inhibition, DNA damage induction, spindle protein, Indirect immunofluorescence, overexpressed INMAP, p 21, LDH 5 isoform, iif, genomic stability impairment
DOI identifier: 10.1371/journal.pone.0115704.g006
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