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Effects of <i>INMAP</i> overexpression on the expression of genes related to proliferation and apoptosis.

By Yan Zhu (112437), Yan Lei (535846), Baochen Du (687895), Yanbo Zheng (687896), Xiangfeng Lu (687897), Tan Tan (192495), Jingting Kang (687898), Le Sun (221947) and Qianjin Liang (535847)

Abstract

<p>(A). Western blot analysis of the three groups of cells (HeLa, Flag-HeLa, and Flag-INMAP) with anti-Bcl-2, anti-p53, anti-p21 and anti-PCNA antibodies. Data shown are representative of three independent experiments. (B). Band quantification was analysed with Image J software. (C). A schematic model illustrating the proposed mechanisms of <i>INMAP</i>-overexpression-induced DNA damage and apoptosis through p53-dependent pathways in transformed cells.</p

Topics: Biological Sciences, chromosome distortion, genomic stability, Induces Genomic Instability, p 53, xenograft growth, centromere integrality, pcna, INMAP Overexpression Inhibits Cell Proliferation, 2AX, monolayer cell cultures, p 21., lactate dehydrogenase, HeLa cells, growth inhibition, DNA damage induction, spindle protein, Indirect immunofluorescence, overexpressed INMAP, p 21, LDH 5 isoform, iif, genomic stability impairment
Year: 2015
DOI identifier: 10.1371/journal.pone.0115704.g006
OAI identifier: oai:figshare.com:article/1298384
Provided by: FigShare
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