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Nicotinamide reduced arsenic and UV-induced 8oxoG levels in the epidermal layer of <i>ex vivo</i> human skin at 45 minutes after UV irradiation (a).

By Benjamin C. Thompson (689642), Gary M. Halliday (634357) and Diona L. Damian (689643)

Abstract

<p>Samples were exposed to either 50μM nicotinamide, 2μM sodium arsenite, PBS (control) with or without 2J/cm<sup>2</sup> of UV. The columns represent the mean ±SEM (n = 3). * = p<0.05, ** = p<0.01 one way ANOVA. <b>Staining of 8oxoG 45 minutes following UV radiation, arsenic and nicotinamide exposure in <i>ex-vivo</i> human skin (b)</b>. The blue staining represents DAPI (nuclear staining). The red staining represents 8oxoG staining.</p

Topics: Uncategorised, HaCaT keratinocytes, DNA repair, uv, arsenic, cyclobutane pyrimidine dimers, photolesion, Nicotinamide Enhances Repair, 2μ M sodium arsenite
Year: 2015
DOI identifier: 10.1371/journal.pone.0117491.g005
OAI identifier: oai:figshare.com:article/1302092
Provided by: FigShare
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