Differential gene expression in the midbrain of human cocaine abusers

Abstract

<p>. Transcript abundances were quantified in specimens from cocaine abusers and control subjects. All subjects died of gunshot wounds (see <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0117580#pone.0117580.t001" target="_blank">Table 1</a> as well as Materials and Methods for case characteristics). Data from cocaine abusers are expressed as a percentage (mean <u>+</u> SEM) of control subjects. * <i>p</i><0.05; ** <i>p</i><0.005 by 1-tailed t-test for independent means. Abbreviations: ACTB, actin; TH, tyrosine hydroxylase; DAT, dopamine transporter; FOXA2, forkhead box A2; H3F3B, histone variant H3, family 3B; NFKBIA, nuclear factor kappa B inhibitor alpha; GADD45B, growth arrest and DNA damage-inducible beta; CCL2, chemokine C-C motif ligand 2; JUN, jun proto-oncogene.</p