Ursolic acid reduced HG-induced collagen I generation in rat mesangial cells.
<p>(A) RT-qPCR analysis of collagen I mRNA expression in each group of cells cultured for 12, 24 and 48 h. (B) Western blot analysis of the collagen I protein expression in each group of cells cultured for 12, 24, 48 and 72 h. (C) The intensities of the bands for collagen I protein in (B) were quantified. #, P<0.01 vs. NG; *, P<0.05 vs. HG; **, P<0.01 vs. HG.</p
Biological Sciences, mesangial cells, rat mesangial cells, LY 294002, Attenuates Diabetic Mesangial Cell Injury, hg, pten, PI 3K kinase B, mirna, mRNA expression.ConclusionsUrsolic acid, lc, ursolic acid conditions, ameliorate cell hypertrophy, PI 3K inhibitor LY 294002, mtt, 85PI, 3II
DOI identifier: 10.1371/journal.pone.0117400.g003
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