Predicted evoked responses of tissue lactate, CMR<sub>glc</sub>, CMR<sub>O2</sub>, oxygen-glucose index (OGI) and BOLD <i>in vivo</i> in humans.

Abstract

<p><b>A</b>. Temporal evolution of the cerebral blood flow chosen as an input to the model during a simulated 900 sec stimulation episode <i>in vivo</i> (grey area). This specific time course closely matches <i>in vivo</i> measurements in humans during imaging experiments [<a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1004036#pcbi.1004036.ref052" target="_blank">52</a>, <a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1004036#pcbi.1004036.ref060" target="_blank">60</a>]. <b>B</b>. Relative fluctuations of tissue lactate concentration during the same stimulation episode as in A. The model predicts an initial lactate dip followed by a 60% increase sustained till the end of the stimulation. The presence of a dip matches experimental data from Mangia et al. [<a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1004036#pcbi.1004036.ref017" target="_blank">17</a>]. <b>C and D</b>. Cerebral metabolic rate of glucose consumption (CMR<sub>glc</sub>) and cerebral metabolic rate of oxygen consumption (CMR<sub>O2</sub>) during the same 900 sec stimulation episode as in A to B. In both cases, the light area corresponds to the contribution of the astrocytic compartment towards the total tissue consumption, while the dark area corresponds to the contribution of the neuronal compartment. While glucose consumption increases by about 40%, the increase is mostly due to the astrocytic compartment (light red) with the neuronal glucose utilization even slightly decreasing at the onset of activation (dark red). On the contrary, while oxygen utilization increases by about 10%, most of this increase is due to the neuronal compartment (dark blue) with the astrocytic oxygen utilization being almost constant (light blue). <b>E</b>. The predicted ratio of CMR<sub>O2</sub> to CMR<sub>glc</sub> or oxygen-glucose index (OGI) during the same 900 sec stimulation episode as in A to D. <b>F</b>. Predicted BOLD signal for the same 900 sec stimulation episode as in A to E. Like the tissue lactate concentration (B), the BOLD shows a clear dip at the onset of activation</p

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Last time updated on 12/02/2018

This paper was published in FigShare.

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