Abstract

<p>1) Pathogenic microbes that invade the airway 2) cause both the resident macrophages and the epithelial cells to secrete IL-8. 3) IL-8 exposure causes intracellular signaling within the epithelial cells that augments <i>de novo</i> protein synthesis and apical localization of CAR<sup>Ex8</sup>. 4) IL-8 simultaneously recruits neutrophils that transmigrate through the epithelium from the basal surface to the apical surface and 5) bind to CAR<sup>Ex8</sup> at the apical surface of the epithelium. 6) AdV entering the airway hijacks the host innate immune response and apical CAR<sup>Ex8</sup> to gain entry into the host cell.</p

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Last time updated on 12/02/2018

This paper was published in FigShare.

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