[4 + 2] Cycloaddition of in Situ Generated 1,2-Diaza-1,3-dienes with Simple Olefins: Facile Approaches to Tetrahydropyridazines
Abstract
A catalyst-free [4 + 2] annulation process between <i>in situ</i> generated 1,2-diaza-1,3-butadienes and simple olefins has been developed. Under mild conditions, the reactions afforded 1,4,5,6-tetrahydropyridazines, which feature a wide range of bioactive compounds, with high yields (up to 99% yield)- Text
- Journal contribution
- Medicine
- Genetics
- Developmental Biology
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- tetrahydro
- Tetrahydro
- olefins
- annulation
- Generated
- bioactive compounds
- Diaza
- Facile Approaches
- yield
- Situ
- Simple Olefins
- diaza
- Cycloaddition