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The effect of changing A- and h-type channel conductances on the current-voltage relationship.

By Ameera X. Patel (455916) and Denis Burdakov (713787)


<p>(A) The left upper panel shows a plot of A-type current against membrane potential over 4 seconds of firing (I-V loop). This relationship was plotted at different A-type channel maximal specific conductances (</p><p></p><p></p><p></p><p><mi>G</mi><mo>‾</mo></p><mi>A</mi><p></p><p></p><p></p>) and in the presence or absence of a tonic, depolarizing, driving current. <p></p><p></p><p></p><p><mi>G</mi><mo>‾</mo></p><mi>A</mi><p></p><p></p><p></p> and driving current values are given above the plot. The left middle panel shows histograms of the percentage time (% time) the membrane spent at various potentials over the 4 seconds of firing, for two <p></p><p></p><p></p><p><mi>G</mi><mo>‾</mo></p><mi>A</mi><p></p><p></p><p></p> values. Firing rates were matched by changing the driving input magnitudes in order to separate the effects of changing <p></p><p></p><p></p><p><mi>G</mi><mo>‾</mo></p><mi>A</mi><p></p><p></p><p></p> (what we were interested in), from the confounding effects of changes in firing rate as a result of changing <p></p><p></p><p></p><p><mi>G</mi><mo>‾</mo></p><mi>A</mi><p></p><p></p><p></p>. The <p></p><p></p><p></p><p><mi>G</mi><mo>‾</mo></p><mi>A</mi><p></p><p></p><p></p> and driving current values for the histograms are given to the right of the plot. The lower left panel shows the voltages at which the channels were active (y axis: <i>m</i><sub>∞</sub> × <i>h</i><sub>∞</sub> / <i>τ</i><sub><i>m</i></sub> × <i>τ</i><sub><i>h</i></sub>). The right panel shows action potential and inter-spike interval (upper) and current (lower) traces for the same <p></p><p></p><p></p><p><mi>G</mi><mo>‾</mo></p><mi>A</mi><p></p><p></p><p></p> / driving current combinations shown in the histograms. (B) The same as panel A for the hyperpolarization-activated inward (h-type) channel, <i>I</i><sub><i>h</i></sub>.<p></p

Topics: Biological Sciences, gain control, voltage window, spike rate adaptation
Year: 2015
DOI identifier: 10.1371/journal.pone.0115431.g008
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Provided by: FigShare
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