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Lpg0393 has a Vps9-like domain.

By Young-Sik Sohn (715070), Ho-Chul Shin (40398), Wei Sun Park (112223), Jianning Ge (112225), Chan-Hee Kim (715071), Bok Luel Lee (412400), Won Do Heo (45317), Jae U. Jung (112232), Daniel John Rigden (59582) and Byung-Ha Oh (85692)


<p>(A) Structural comparison with the catalytic core of Rabex-5. Four residues important for the GEF activity of Rabex-5 and corresponding Lpg0393 residues are shown in sticks (<i>left</i>) and highlighted (<i>right</i>). Asp313 and Tyr354 are identically conserved in Lpg0393, while Pro317 and Glu351 are substituted by unrelated amino acids. (B) Topological comparison with the catalytic core of Rabex-5. The domain organization is reversed, and the topology of the helical bundle domain is reversed in the two proteins. (C) Structure-based sequence alignment. The N-terminal domain of Lpg0393 and the Vps9 domains of Rabex-5 and <i>Arabidopsis</i> Vps9a are aligned. The secondary structural elements of Lpg0393 and Rabex-5 are shown at the top and bottom of the alignment, respectively. The four highlighted residues in <i>A</i> are indicated by arrows.</p

Topics: Biological Sciences, 290 effector proteins, Lpg 0393, Rab 22 Legionella pneumophila
Year: 2015
DOI identifier: 10.1371/journal.pone.0118683.g003
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Provided by: FigShare
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