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Simulated model behavior in abnormal physiological conditions obtained by varying some parameters.

By Simona Panunzi (81738), Laura D’Orsi (715819), Daniela Iacoviello (715820) and Andrea De Gaetano (81740)

Abstract

<p>Panel A reports the Time course of model-simulated arterial pressure (mmHg), on the left, and the model-simulated cerebral blood flow velocity (CBFV, mL/sec), on the right, varying the parameter <i>k</i><sub><i>xf</i></sub>. The continuous line describes the trend in the physiological situation (<i>k</i><sub><i>xf</i></sub> = 0.5), the dashed black line describes the trend with <i>k</i><sub><i>xf</i></sub> = 0.7 whereas the dashed gray line describes the trend with <i>k</i><sub><i>xf</i></sub> = 0.3. Panel B reports the time course of model-simulated arterial pressure (mmHg), on the left, and model-simulated cerebral blood flow velocity (CBFV, mL/sec), on the right, varying the parameter <i>k</i><sub><i>h</i></sub>. The continuous line describes the trend in the physiological situations (<i>k</i><sub><i>h</i></sub> = 0.05), the dashed black line describes the trend with <i>k</i><sub><i>h</i></sub> = 0.07 and the dashed gray line describes the trend with <i>k</i><sub><i>h</i></sub> = 0.02. Panel C reports the time course of model-simulated arterial pressure (mmHg), on the left, and model-simulated cerebral blood flow velocity (CBFV, mL/sec), on the right, varying the parameter <i>k</i><sub><i>xca</i></sub>. The continuous line describes the trend in the physiological situations (<i>k</i><sub><i>xca</i></sub> = 0.01), the dashed black line describes the trend with <i>k</i><sub><i>xca</i></sub> = 0.06 whereas the dashed gray line describes the trend for <i>k</i><sub><i>xca</i></sub> = 0.005.</p

Topics: Uncategorised, Stochastic Delay, postural changes, SDDE, blood flow velocity signals, time course, model
Year: 2015
DOI identifier: 10.1371/journal.pone.0118456.g005
OAI identifier: oai:figshare.com:article/1364172
Provided by: FigShare
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