oai:figshare.com:article/1364886Experimental set-up for monocyte infusions, cognitive evaluations and neurobiological analysis.
Abstract
<p>At 5 months of age (mice do not display any extracellular plaques), APPSwDI mice were evaluated by the black/white (B/W) box and 8-arm radial maze, which included both training, learning and retention sessions. Following these evaluations, mice were infused intravenously with (I) approx. 5 x 10<sup>6</sup> young CD11b+ monocytes (isolated from 14 day-old wildtype mice; n = 8) or with (II) saline (n = 7). Every two weeks, animals were tested in the B/W box and 8-arm maze for changes in anxiety and memory, respectively. Intravenous infusions were repeated at months 6 and 7, following cognitive evaluations. At 8 months of age, mice were sacrificed (TAKE) following retention and analyzed.</p- Image
- Figure
- Uncategorised
- monocytic cells
- cholinergic neurodegeneration
- Other disease features
- β plaques
- surface marker expression
- 5 months
- 1 μ M
- plaque burden
- cytokine levels
- Recent studies
- CD 11b monocytes
- 8 months
- memory function
- Pluriselect CD 11b isolation method
- Peripheral monocytes
- tail vein
- adult APPSwDI mice results
- infusion
- AD mouse model
- 7 months
- AD brain
- disease propagation
- Intravenous Infusion
- β plaque clearance
- plaque deposition
- data show
- FACS analysis
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Provided original full text linkoai:figshare.com:article/1364886Last time updated on 2/12/2018This paper was published in FigShare.
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