Experimental set-up for monocyte infusions, cognitive evaluations and neurobiological analysis.


<p>At 5 months of age (mice do not display any extracellular plaques), APPSwDI mice were evaluated by the black/white (B/W) box and 8-arm radial maze, which included both training, learning and retention sessions. Following these evaluations, mice were infused intravenously with (I) approx. 5 x 10<sup>6</sup> young CD11b+ monocytes (isolated from 14 day-old wildtype mice; n = 8) or with (II) saline (n = 7). Every two weeks, animals were tested in the B/W box and 8-arm maze for changes in anxiety and memory, respectively. Intravenous infusions were repeated at months 6 and 7, following cognitive evaluations. At 8 months of age, mice were sacrificed (TAKE) following retention and analyzed.</p

Similar works

Full text

oaioai:figshare.com:article/1364886Last time updated on 2/12/2018

This paper was published in FigShare.

Having an issue?

Is data on this page outdated, violates copyrights or anything else? Report the problem now and we will take corresponding actions after reviewing your request.