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Challenge study design (Phase II).

By Sundaram A. Vishwanathan (117351), Monica R. Morris (719144), Richard J. Wolitski (387008), Wei Luo (80175), Charles E. Rose (475607), Dianna M. Blau (719145), Theodros Tsegaye (719146), Sherif R. Zaki (130417), David A. Garber (220619), Leecresia T. Jenkins (719147), Tara C. Henning (719148), Dorothy L. Patton (359415), R. Michael Hendry (352702), Janet M. McNicholl (139582) and Ellen N. Kersh (352697)

Abstract

<p>Lubricant was applied non-traumatically for three weeks, on two consecutive days per week. The animal was challenged with SHIV<sub>SF162p3</sub> 30 minutes after the sixth lubricant application (open triangle). To check for plasma viremia and virus shedding, samples were collected for at least 2 weeks post-peak viremia. Not shown are baseline blood draws that were performed before the first lubricant application to ensure that the animal is not infected.</p

Topics: Uncategorised, SHIVSF 162P infection, Macaque Model Induces Acute Cytotoxicity, epithelial tissue sloughing, SHIV Infection BackgroundPersonal lubricant use, std, pq, SHIV infection risk, pbs, rectal tissues, polymer polyquaternium 15, aid, control buffer applications, control buffer 30 minutes, model
Year: 2015
DOI identifier: 10.1371/journal.pone.0120021.g004
OAI identifier: oai:figshare.com:article/1372063
Provided by: FigShare
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