<p>ER retention of CD112 is mediated by UL141 and only detected upon depletion of US2 or TRC8. (<b>A</b>) HFF infected with mock, HCMV wild-type, ΔUS2 or ΔUL141 (moi 5) were analyzed for the indicated proteins at 72 hours post infection, in the presence (shTRC8+) or absence (shTRC8-) of TRC8 depletion. (<b>B</b>) UL141 retains CD112 in the ER prior to TRC8-dependent degradation by US2. THP-1 cells stably expressing US2, US11, UL141-Myc or shTRC8 were solubilized in 1% digitonin, immunoprecipitated with anti-Myc antibody and the indicated proteins visualized by immunoblot. See also <b><a href="http://www.plospathogens.org/article/info:doi/10.1371/journal.ppat.1004811#ppat.1004811.s004" target="_blank">S4 Fig</a></b>.</p

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Last time updated on 12/02/2018

This paper was published in FigShare.

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