Spectroscopic Investigation on the Interactions between Cationic Surfactants and Bovine Serum Albumin


<div><p>Physicochemical studies on the interaction of cationic surfactants dodecyltrimethylammonium bromide (DTAB), <i>N</i>-dodecyl-<i>N</i>-2-hydroxyethyl-<i>N,N</i>-dimethylammonium bromide (C<sub>12</sub>HDAB), and <i>N</i>-dodecyl-<i>N,N</i>-2-dihydroxyethyl-<i>N</i>-methyl ammonium bromide (C<sub>12</sub>DHAB) with bovine serum albumin (BSA) were performed by fluorimetry, circular dichroism (CD) spectroscopy, dynamic light scattering, and ξ-potential measurements. The quenching efficiency of the intrinsic fluorescence of BSA and the interaction strength with BSA increased with increasing numbers of hydroxyethyl constituents in the head group. In each of the surfactant/BSA systems studied, the specific binding site was Trp-213 and the hydrophobic interaction was predominant while a contribution of the hydrogen bond was also observed in the presence of hydroxyethyl.</p></div

Similar works

Full text

oaioai:figshare.com:article/1381891Last time updated on 2/12/2018

This paper was published in FigShare.

Having an issue?

Is data on this page outdated, violates copyrights or anything else? Report the problem now and we will take corresponding actions after reviewing your request.