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The calcium channel blockers Diltiazem and Nifedipine have no effect on PTH changes in gene expression except for Keratocan.

By Matthew Prideaux (323913), Sarah L. Dallas (735119), Ning Zhao (84707), Erica D. Johnsrud (735120), Patricia A. Veno (735121), Dayong Guo (735122), Yuji Mishina (70830), Stephen E. Harris (451476) and Lynda F. Bonewald (342609)


<p>(A) Real-time PCR analysis showing effects of Diltiazem on gene expression in mature IDG-SW3 cells. No effects on PTH changes in gene expression were observed (n = 3±SD, p<0.05 relative to control (a), PTH (b), DH (c) and PTH & DH (d)). (B) Effects of Nifedipine on gene expression. No effects of Nifedipine were observed on PTH induced gene expression except that Nifedipine inhibited PTH induction of <i>Kera</i>. (n = 3±SD, p<0.05 relative to control (a), PTH (b), NI (c) and PTH & NI (d)) Expression was normalized to <i>Actb</i>.</p

Topics: Biological Sciences, Parathyroid Hormone Induces Bone Cell Motility, Mature Osteocyte Phenotype, pkc, pka, osteocyte marker expression, 1r, dentin matrix 1, Independent Mechanisms Parathyroid Hormone, PTH type 1 receptor, cell motility effect, PTH treatment, Pi 3K agonists, gfp, gene expression profile
Year: 2015
DOI identifier: 10.1371/journal.pone.0125731.g007
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Provided by: FigShare
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