The calcium channel blockers Diltiazem and Nifedipine have no effect on PTH changes in gene expression except for Keratocan.
<p>(A) Real-time PCR analysis showing effects of Diltiazem on gene expression in mature IDG-SW3 cells. No effects on PTH changes in gene expression were observed (n = 3±SD, p<0.05 relative to control (a), PTH (b), DH (c) and PTH & DH (d)). (B) Effects of Nifedipine on gene expression. No effects of Nifedipine were observed on PTH induced gene expression except that Nifedipine inhibited PTH induction of <i>Kera</i>. (n = 3±SD, p<0.05 relative to control (a), PTH (b), NI (c) and PTH & NI (d)) Expression was normalized to <i>Actb</i>.</p
Biological Sciences, Parathyroid Hormone Induces Bone Cell Motility, Mature Osteocyte Phenotype, pkc, pka, osteocyte marker expression, 1r, dentin matrix 1, Independent Mechanisms Parathyroid Hormone, PTH type 1 receptor, cell motility effect, PTH treatment, Pi 3K agonists, gfp, gene expression profile
DOI identifier: 10.1371/journal.pone.0125731.g007
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