SerpinB2 binds misfolded proteins and suppresses BSA aggregation <i>in vitro</i>.
<p><b>A–C.</b> Dose dependent binding of SerpinB2 to native and misfolded proteins was determined using ELISA. Data represent mean absorbance (A<sub>490</sub>) ± SEM (n = 3); <b>D.</b> Real-time turbidity assay of DTT-induced BSA aggregation in the absence or presence of SerpinB2, αB-crystallin or SerpinB14 (w/w ratio). Data represent mean absorbance (A<sub>490</sub>) ± SEM (n = 3).</p
Biological Sciences, pai, SerpinB 2, amyloid beta fibril formation, ups, serine protease inhibitors, compartmentalize aggregating proteins, Cytoprotective Inclusion Formation SerpinB 2, display cytoprotective properties, mef, SerpinB 2 expression, Binding Misfolded Proteins, Inclusion body formation, cell viability, clade B family, GFP reporter system, urokinase plasminogen activator
DOI identifier: 10.1371/journal.pone.0130136.g004
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