Causal network to depict functional relations between sensitivity-specific and resistance-specific signature genes.
Abstract
<p>The network was reconstructed from canonical signaling pathways regulated by signature genes and a signature specific direct interaction network. Sensitivity-specific signature genes are highlighted with blue thermometers, resistance-specific genes with red thermometers.</p- Image
- Figure
- Uncategorised
- patient data
- drug discovery
- treatment arms
- signature genes
- trial design
- Predict Treatment Outcome
- drug sensitivity models
- cancer indications
- stage trials
- trial results
- splitting strategy
- patient stratification
- patient inclusion parameter
- canonical pathways
- GEO expression datasets
- erlotinib
- Identify Cell Line Derived Translational Biomarkers
- plsr
- modeling framework
- Sorafenib Development
- model building
- Such translational biomarkers
- squares regression
- trial phases