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Cytokine profiles in the distal colon of colitic mice correlate with increased CD103<sup>+</sup>CD11b<sup>+</sup> P2 DCs in the same colon segment.

By Ulf A. Wenzel (580255), Caroline Jonstrand (580257), Gunnar C. Hansson (211850) and Mary Jo Wick (580262)

Abstract

<p>LP cells of the other half of the same distal colon segment of the same mice used for cytokine analyses in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0130750#pone.0130750.g003" target="_blank">Fig 3</a> were analyzed by flow cytometry. Cells were gated as in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0130750#pone.0130750.g002" target="_blank">Fig 2A</a>. (A-C) The frequency of DCs belonging to subsets P1 (A), P2 (B) or P3 (C) among viable MHCII<sup>+</sup>CD11c<sup>hi</sup> cells is shown. (D-E) The absolute number of DCs belonging to subsets P1 (D), P2 (E) or P3 (F) among 10<sup>6</sup> viable LP cells is depicted. Each symbol represents an individual mouse and the solid line indicates the mean of each group. Statistical significance between groups was assessed using the Kruskal-Wallis test followed by Dunn’s multiple comparison test.</p

Topics: Uncategorised, Th 1 differentiation, Th 1 cells, Th 17 cells, ifn, uc, Colitis Mucus alterations, DC subsets, colitis spread proximally, T cell proliferation, t cells, tnf, il
Year: 2015
DOI identifier: 10.1371/journal.pone.0130750.g004
OAI identifier: oai:figshare.com:article/1467228
Provided by: FigShare
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